Metabolism of the microregions of human breast cancer

被引：10

作者：

dos Santos, MA ^{[1
]}

Borges, JBR ^{[1
]}

de Almeida, DCG ^{[1
]}

Curi, R ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Phys & Biophys, BR-05508900 Sao Paulo, Brazil

来源：

CANCER LETTERS | 2004年 / 216卷 / 02期

关键词：

glucose metabolism; glutamine metabolism; insulin responsiveness; tumor microregions; human breast cancer;

D O I：

10.1016/j.canlet.2004.04.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center>periphery>mammary gland. Insulin caused a marked increase of glucose consumption and lactate production by incubated slices of mammary gland but had no effect on both microregions of the tumor. Therefore, human breast cancer presents metabolic microregions. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：243 / 248

页数：6

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