Structural biology - A mechanism for all polymerases

被引：483

作者：

Steitz, TA

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

NATURE | 1998年 / 391卷 / 6664期

关键词：

D O I：

10.1038/34542

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Replication of the genome is one of the most fundamental of biological activities, hence the interest in the mechanism by which the enzymes concerned -- the polynucleotide polymerases -- carry out the process. The co-crystal structures of the DNA polymerase that replicates bacteriophage T7, and of theBacillus stearothermophilusDNA polymerase large fragment, provide significant insights into the catalytic mechanism, fidelity and processivity of DNA polymerases.

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页码：231 / 232

页数：2

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