Enhanced photothermal therapy assisted with gold nanorods using a radially polarized beam

被引：51

作者：

Kang, Hong ^{[1
]}

Jia, Baohua ^{[1
]}

Li, Jingliang ^{[1
]}

Morrish, Dru ^{[1
]}

Gu, Min ^{[1
]}

机构：

[1] Swinburne Univ Technol, Ctr Microphoton, Fac Engn & Ind Sci, Hawthorn, Vic 3122, Australia

来源：

APPLIED PHYSICS LETTERS | 2010年 / 96卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

cancer; cellular biophysics; gold; laser beam effects; patient treatment; photothermal effects;

D O I：

10.1063/1.3302461

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We report on the use of a radially polarized beam for photothermal therapy of cancer cells labeled with gold nanorods. Due to a three-dimensionally distributed electromagnetic field in the focal volume, the radially polarized beam is proven to be a highly efficient laser mode to excite gold nanorods randomly oriented in cancer cells. As a result, the energy fluence for effective cancer cell damage is reduced to one fifth of that required for a linearly polarized beam, which is only 9.3% of the medical safety level.

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页数：3

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