Curdlan gels as protein drug delivery vehicles

被引：45
作者：
Kim, BS [1 ]
Jung, ID
Kim, JS
Lee, J
Lee, IY
Lee, KB
机构：
[1] Konyang Univ, Coll Med, Dept Chem Engn, Nonsan 320711, Chungnam, South Korea
[2] Konyang Univ, Coll Med, Dept Chem, Nonsan 320711, Chungnam, South Korea
[3] Konyang Univ, Coll Med, Dept Biochem, Nonsan 320711, Chungnam, South Korea
[4] Korea Res Inst Biosci & Biotechnol, Biochem Proc Res Unit, Taejon 305600, South Korea
来源：
BIOTECHNOLOGY LETTERS | 2000年 / 22卷 / 14期
关键词：
curdlan; gel; hydroxyethylation; protein drug delivery; urea;
D O I：
10.1023/A:1005636205036
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The use of curdlan, a natural beta-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 degrees C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while BSA was completely released after 45-100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm(-2)) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm(-2)).
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页码：1127 / 1130
页数：4
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