Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats

被引：201
作者：
Hsu, FL
Liu, IM
Kuo, DH
Chen, WC
Su, HC
Cheng, JT [1 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan
[2] Taipei Med Univ, Sch Pharm, Inst Pharmacognosy, Taipei 11031, Taiwan
[3] Jin Ai Municipal Hosp, Dept Chinese Med, Taipei 10501, Taiwan
[4] Tajen Inst Technol, Dept Pharm, Yen Pou 90701, Ping Tung Shien, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 06期
关键词：
D O I：
10.1021/np0203887
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
引用
收藏
页码：788 / 792
页数：5
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