Efficient synthesis of thiazoloquinazolinone derivatives

被引：54

作者：

Alexandre, FR

Berecibar, A

Wrigglesworth, R

Besson, T

机构：

[1] Univ Rochelle, UFR Sci Fondamentales & Sci Ingenieur, Grp Chim Organ, Lab Genie Prot & Cellulaire,EA3169, F-17042 La Rochelle 1, France

[2] PFIZER, Global Res & Dev, Fresnes Labs, F-94265 Fresnes, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

thiazoloquinazolinones; quinazolines; 4,5-dichloro-1,2,3-dithiazolium chloride; microwave-assisted chemistry;

D O I：

10.1016/S0040-4039(03)01026-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An original route to the rare 8H-thiazolo[5,4-f]quinazolin-9-one 1 and the novel 7H-thiazolo[4,5-h]quinazolin-6-one 2 is described. Access to the regioisomers was realized by fusion of a thiazole and a quinazoline ring via Appel's salt chemistry. Thermal reactions were carried Out using a focused microwave reactor. reducing the overall time of the multi-step synthesis. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4455 / 4458

页数：4

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