Improvement of neurological symptoms and memory and emotional status in a case of seronegative Sneddon syndrome with cyclophosphamide

被引：17

作者：

Hannon, Peter M. ^{[1
]}

Kuo, Sheng-Han ^{[1
]}

Strutt, Adriana M. ^{[1
]}

York, Michele K. ^{[1
]}

Kass, Joseph S. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2010年 / 112卷 / 06期

关键词：

Seronegative Sneddon syndrome; Cognitive decline; Cyclophosphamide; Dementia in the young; CEREBROVASCULAR EVENTS; NATURAL COURSE; ANTIBODIES; DEMENTIA; LESIONS;

D O I：

10.1016/j.clineuro.2010.04.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sneddon syndrome (SS) is characterized by livedo racemosa, recurrent ischemic strokes, and often progressive vascular dementia. Treatment options for SS center on either anticoagulation or immunosuppression to prevent strokes and to dissipate the skin findings, with these modalities based historically on the presence or absence of antiphospholipid antibodies (APA) respectively. However, few effective treatments have been reported to reverse the cognitive decline in SS. We report a case of a woman with seronegative SS (absence of APA) with cognitive decline who demonstrated objective and subjective improvements in her memory and emotional functioning after treatment with cyclophosphamide. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：544 / 547

页数：4

共 15 条

[1]

Adair JC, 2001, NEUROPSY NEUROPSY BE, V14, P197

[2] The natural course of Sneddon syndrome:: clinical and magnetic resonance imaging findings in a prospective six year observation study [J].

Boesch, SM ;

Plörer, AL ;

Auer, AJ ;

Poewe, W ;

Aichner, FT ;

Felber, SR ;

Sepp, NT .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (04) :542-544

[3] SNEDDONS SYNDROME WITH GRANULOMATOUS LEPTOMENINGEAL INFILTRATION [J].

BOORTZMARX, RL ;

CLARK, HB ;

TAYLOR, S ;

WESA, KM ;

ANDERSON, DC .

STROKE, 1995, 26 (03) :492-495

[4]

Devuyst G, 1996, STROKE, V27, P1008

[5] Therapy of Sneddon syndrome [J].

Flöel, A ;

Imai, T ;

Lohmann, H ;

Bethke, F ;

Sunderkötter, C ;

Droste, DW .

EUROPEAN NEUROLOGY, 2002, 48 (03) :126-132

[6] Sneddon syndrome with or without antiphospholipid antibodies -: A comparative study in 46 patients [J].

Francès, C ;

Papo, T ;

Wechsler, B ;

Laporte, JL ;

Biousse, V ;

Piette, JC .

MEDICINE, 1999, 78 (04) :209-219

[7] SNEDDONS SYNDROME IS A THROMBOTIC VASCULOPATHY - NEUROPATHOLOGIC AND NEURORADIOLOGIC EVIDENCE [J].

GESCHWIND, DH ;

FITZPATRICK, M ;

MISCHEL, PS ;

CUMMINGS, JL .

NEUROLOGY, 1995, 45 (03) :557-560

[8] PSYCHOTHERAPY OUTCOME RESEARCH - METHODS FOR REPORTING VARIABILITY AND EVALUATING CLINICAL-SIGNIFICANCE [J].

JACOBSON, NS ;

FOLLETTE, WC ;

REVENSTORF, D .

BEHAVIOR THERAPY, 1984, 15 (04) :336-352

[9] ANTICARDIOLIPIN ANTIBODIES IN SNEDDONS SYNDROME [J].

KALASHNIKOVA, LA ;

NASONOV, EL ;

KUSHEKBAEVA, AE ;

GRACHEVA, LA .

NEUROLOGY, 1990, 40 (03) :464-467

[10] Sneddon's syndrome (livedo racemosa and cerebral infarction) presenting psychiatric disturbance and shortening of fingers and toes [J].

Kume, M ;

Imai, H ;

Motegi, M ;

Miura, AB ;

Namura, L .

INTERNAL MEDICINE, 1996, 35 (08) :668-673

← 1 2 →