Programming Molecular Association and Viscoelastic Behavior in Protein Networks

被引：93
作者：
Dooling, Lawrence J. [1 ]
Buck, Maren E. [1 ,2 ]
Zhang, Wen-Bin [1 ,3 ]
Tirrell, David A. [1 ]
机构：
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
[2] Smith Coll, Dept Chem, Northampton, MA 01063 USA
[3] Peking Univ, Coll Chem & Mol Engn, Ctr Soft Matter Sci & Engn, Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 23期
基金：
美国国家科学基金会;
关键词：
TOUGH HYDROGELS; POLYMERS;
D O I：
10.1002/adma.201506216
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A set of recombinant artificial proteins that can be crosslinked, by either covalent bonds or association of helical domains or both, is described. The designed proteins can be used to construct molecular networks in which the mechanism of crosslinking determines the time-dependent responses to mechanical deformation.
引用
收藏
页码：4651 / 4657
页数：7
相关论文
共 32 条
[1]   Enzymatically Cross-Linked Tilapia Gelatin Hydrogels: Physical, Chemical, and Hybrid Networks [J].
Bode, Franziska ;
da Silva, Marcelo Alves ;
Drake, Alex F. ;
Ross-Murphy, Simon B. ;
Dreiss, Cecile A. .
BIOMACROMOLECULES, 2011, 12 (10) :3741-3752
[2]   Substrate stress relaxation regulates cell spreading [J].
Chaudhuri, Ovijit ;
Gu, Luo ;
Darnell, Max ;
Klumpers, Darinka ;
Bencherif, Sidi A. ;
Weaver, James C. ;
Huebsch, Nathaniel ;
Mooney, David J. .
NATURE COMMUNICATIONS, 2015, 6
[3]   The Protein-Folding Problem, 50 Years On [J].
Dill, Ken A. ;
MacCallum, Justin L. .
SCIENCE, 2012, 338 (6110) :1042-1046
[4]  
Goodwin JW, 2008, RHEOLOGY FOR CHEMISTS: AN INTRODUCTION, P1
[5]   N-Terminal Aliphatic Residues Dictate the Structure, Stability, Assembly, and Small Molecule Binding of the Coiled-Coil Region of Cartilage Oligomeric Matrix Protein [J].
Gunasekar, Susheel K. ;
Asnani, Mukta ;
Limbad, Chandani ;
Haghpanah, Jennifer S. ;
Hom, Wendy ;
Barra, Hanna ;
Nanda, Soumya ;
Lu, Min ;
Montclare, Jin Kim .
BIOCHEMISTRY, 2009, 48 (36) :8559-8567
[6]   Increasing the Maximum Achievable Strain of a Covalent Polymer Gel Through the Addition of Mechanically Invisible Cross-Links [J].
Kean, Zachary S. ;
Hawk, Jennifer L. ;
Lin, Shaoting ;
Zhao, Xuanhe ;
Sijbesma, Rint P. ;
Craig, Stephen L. .
ADVANCED MATERIALS, 2014, 26 (34) :6013-+
[7]   Transient binding and dissipation in cross-linked actin networks [J].
Lieleg, O. ;
Claessens, M. M. A. E. ;
Luan, Y. ;
Bausch, A. R. .
PHYSICAL REVIEW LETTERS, 2008, 101 (10)
[8]   Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition [J].
Lutolf, MP ;
Hubbell, JA .
BIOMACROMOLECULES, 2003, 4 (03) :713-722
[9]   Sequence-Controlled Polymers [J].
Lutz, Jean-Francois ;
Ouchi, Makoto ;
Liu, David R. ;
Sawamoto, Mitsuo .
SCIENCE, 2013, 341 (6146) :628-+
[10]   THE 3-DIMENSIONAL STRUCTURE OF THE 10TH TYPE-III MODULE OF FIBRONECTIN - AN INSIGHT INTO RGD-MEDIATED INTERACTIONS [J].
MAIN, AL ;
HARVEY, TS ;
BARON, M ;
BOYD, J ;
CAMPBELL, ID .
CELL, 1992, 71 (04) :671-678
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