Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-Mediated Gene Expression

被引：11

作者：

Imoto, Takuma ^{[1
]}

Kawase, Akihiro ^{[1
]}

Minoshima, Masafumi ^{[1
]}

Yokoyama, Tatsushi ^{[2
]}

Bito, Haruhiko ^{[2
]}

Kikuchi, Kazuya ^{[1
,3
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Div Adv Sci & Biotechnol, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neurochem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[3] Osaka Univ, Immunol Frontier Res Ctr, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 01期

关键词：

D O I：

10.1021/acs.orglett.9b03568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct optochemical method for regulating gene function has been developed based on uncaging of an inactive caged precursor that fragments to produce a CREB (CAMP-response element binding protein) inhibitor that binds to an endogenous transcription factor responsible for regulating CREB-mediated gene expression levels.

引用

页码：22 / 25

页数：4

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