Chichibabin/isoChichibabin pyridinium synthesis of ma'edamines C and D

被引：4

作者：

Hirose, Mika ^{[1
]}

Tanaka, Nao ^{[1
]}

Usuki, Toyonobu ^{[1
]}

机构：

[1] Sophia Univ, Fac Sci & Technol, Dept Mat & Life Sci, Chiyoda Ku, 7-1 Kioicho, Tokyo 1028554, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2021年 / 46卷

关键词：

Ma'edamine; Chichibabin pyridinium synthesis; Total synthesis; BROMOTYROSINE ALKALOIDS; CROSS-LINKAGES;

D O I：

10.1016/j.bmcl.2021.128165

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ma'edamines C and D were isolated from an Okinawan marine sponge and exhibited a unique tetrasubstituted pyridinium skeleton. The proposed biosynthetic pathway is similar to that of desmosine and isodesmosine, which are elastin-crosslinking amino acids. In this study, first total synthesis of ma'edamines C and D was achieved via Pr(OTf)3-promoted Chichibabin/isoChichibabin pyridinium synthesis starting from the corresponding aldehydes and amine.

引用

页数：4

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