Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

被引：5

作者：

Yang, Shunping ^{[1
]}

Wu, Yanfang ^{[1
]}

Zhang, Hao ^{[1
]}

Sun, Jin ^{[1
]}

Liu, Yan ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2021年 / 66卷 / 05期

关键词：

CLOPIDOGREL HYDROGEN SULFATE; ERLOTINIB HYDROCHLORIDE; METASTABLE POLYMORPH; WATER; ISOPROPANOL;

D O I：

10.1021/acs.jced.0c01073

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Ticagrelor (TCG) is a P2Y(12) platelet inhibitor and has several crystal forms including Form II and Form V. In this work, it has been confirmed that Form II TCG would gradually transform to Form V in selected solvents. According to the crystal form stability, a dynamic method was adopted to measure the solubility of Form II TCG in six pure solvents (n-propanol, isopropanol, n-butanol, 2-butanol, ethyl acetate, and isopropyl acetate). The solubility of Form V TCG in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, and cyclohexanone) was measured by a static method. The solubility measurement temperature range was from 273.15 to 313.15 K. The experimental solubility data were correlated by the modified Apelblat model and the lambda h model. It was shown that the calculated solubility was consistent with the experimental data.

引用

页码：2022 / 2033

页数：12

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