Synthesis of high specific activity [ethyl-1, 2-3H]-labeled chlorpyrifos oxon and diazoxon

被引：0

作者：

Zhang, NJ ^{[1
]}

Morimoto, H ^{[1
]}

Williams, PG ^{[1
]}

Casida, JE ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Environm Sci Policy & Mangement, Environm Chem & Toxicol Lab, Berkeley, CA 94720 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 13期

关键词：

acetylcholinesterase; chlorpyrifos oxon; diazoxon; insecticide; tritium; isotope exchange;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[Ethyl-1,2-H-3]Chlorpyrifos oxon and [ethyl-1,2-H-3]diazoxon were synthesized at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. The high specific activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is applicable to the toxicologically-important oxon metabolites of many commercial O,O-diethyl phosphorothioate pesticides.

引用

页码：1275 / 1282

页数：8

共 11 条

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