Design, synthesis, and anti-inflammatory activity of caffeoyl salicylate analogs as NO production inhibitors

被引：10

作者：

Yu, Pan ^{[1
]}

Xia, Chao-Jie ^{[1
]}

Li, Dong-Dong ^{[1
]}

Ni, Jun-Jun ^{[1
]}

Zhao, Lin-Guo ^{[1
]}

Ding, Gang ^{[2
]}

Wang, Zhen-Zhong ^{[2
]}

Xiao, Wei ^{[2
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, 159 Long Pan Rd, Nanjing 210037, Jiangsu, Peoples R China

[2] Jiangsu Kanion Pharmaceut Co Ltd, 58 Haichang South Rd, Lianyungang 222001, Jiangsu, Peoples R China

来源：

FITOTERAPIA | 2018年 / 129卷

关键词：

Chlorogenic acid; Anti-inflammatory; Caffeoyl salicylate analogs; Nitric oxide synthase; CHLOROGENIC ACID; DATABASE;

D O I：

10.1016/j.fitote.2018.05.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chlorogenic acid (CGA) has been reported to exhibit potent anti-inflammatory activity. However, the development of anti-inflammatory agent based on CGA has not been investigated. In this paper, a series of caffeoyl salicylate compounds derived from CGA were designed, synthesized, and evaluated by LPS-induced nitric oxide synthase inhibition and QRT-PCR technique. Most compounds showed modest activity to inhibit production of nitric oxide (NO) in RAW 264.7 cells induced by lipopolysaccharides (LPS). Among these compounds, QRT-PCR and western blotting results indicated that compounds 6b, 6c, 6f, 6g and D104 that possess 5-member ring or 6-member ring caused a significant inhibition against expression of the iNOS2 in LPS-induced macrophages. In addition, cytotoxic assay displayed most derivatives have good safety in vitro. This new promising scaffold could be further exploited for the development of anti-inflammatory agent in the future.

引用

页码：25 / 33

页数：9

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