Sudden death occurring after anti-Hu associated paraneoplastic cerebellar degeneration and dysautonomia revealing a small cell lung carcinoma

被引：1

作者：

Mirouse, A. ^{[1
]}

Gobert, D. ^{[1
]}

Chamouard, J. -M. ^{[1
]}

Lordache, L. ^{[1
]}

Mekinian, A. ^{[1
]}

Fain, O. ^{[1
]}

机构：

[1] Univ Paris 13, Hop Jean Verdier, AP HP, Serv Med Interne, F-93140 Bondy, France

来源：

REVUE DE MEDECINE INTERNE | 2014年 / 35卷 / 11期

关键词：

Paraneoplastic syndromes; Nervous system; Paraneoplastic cerebellar degeneration; Autonomic nervous system diseases; Sudden death; Arrhytmias; AUTONOMIC NEUROPATHY; ENCEPHALOMYELITIS; NEURONOPATHY; ANTIBODIES;

D O I：

10.1016/j.revmed.2013.12.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Paraneoplastic syndromes are a rare cancer complication with a frequent subacute evolution. Observation. - A 62-year-old man was admitted presenting with a cerebellar syndrome and orthostatic hypotension with dysautonomia. Anti-Hu antibody research Was positive. A subcarinal adenopathy biopsy found out a small cell lung carcinoma. Despite a treatment with immunoglobulin and chemotherapy, the patient died suddenly, after a raise of dysautonomia symptoms. Conclusion. - Sudden death observations represent exceptional complications of paraneoplastic syndrome. They might be secondary to arrhythmias, ictal asystol or laryngospasm. Systematic research of paroxystic heart arrhythmias with holter-ECG in paraneoplastic syndrome may prevent sudden deaths. (C) 2014 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：757 / 759

页数：3