How Can We Engineer CAR T Cells to Overcome Resistance?

被引：16

作者：

Glover, Maya ^{[1
]}

Avraamides, Stephanie ^{[2
]}

Maher, John ^{[1
,2
,3
,4
]}

机构：

[1] Guys Hosp, Leucid Bio Ltd, London SE1 9RT, England

[2] Guys Hosp, Kings Coll London, Sch Canc & Pharmaceut Sci, London SE1 9RT, England

[3] Kings Coll Hosp NHS Fdn Trust, Dept Clin Immunol & Allergy, London SE5 9RS, England

[4] Eastbourne Hosp, Dept Immunol, Eastbourne BN21 2UD, E Sussex, England

来源：

BIOLOGICS-TARGETS & THERAPY | 2021年 / 15卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

chimeric antigen receptor; cancer; immunotherapy; T-cell; resistance; CHIMERIC-ANTIGEN-RECEPTOR; FIBROBLAST ACTIVATION PROTEIN; ANTITUMOR-ACTIVITY; B-CELL; TUMOR-ANTIGEN; ADOPTIVE IMMUNOTHERAPY; SELECTIVE EXPANSION; INDUCE REMISSIONS; LYMPHOMA ACTIVITY; HOST IMMUNITY;

D O I：

10.2147/BTT.S252568

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy has achieved unrivalled success in the treatment of B cell and plasma cell malignancies, with five CAR T cell products now approved by the US Food and Drug Administration (FDA). However, CAR T cell therapies for solid tumours have not been nearly as successful, owing to several additional challenges. Here, we discuss mechanisms of tumour resistance in CAR T cell therapy and the emerging strategies that are under development to engineer CAR T cells to overcome resistance.

引用

页码：175 / 198

页数：24

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