Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives

被引：6

作者：

Saglik, Begum Nurpelin ^{[1
]}

Ozkay, Yusuf ^{[1
]}

Ozkay, Umide Demir ^{[2
]}

Gencer, Hulya Karaca ^{[3
]}

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] Anadolu Univ, Fac Pharm, Dept Pharmacol, TR-26470 Eskisehir, Turkey

[3] Anadolu Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-26470 Eskisehir, Turkey

来源：

JOURNAL OF CHEMISTRY | 2014年 / 2014卷

关键词：

ANTIBACTERIAL ACTIVITY; ACETYLCHOLINESTERASE; DESIGN;

D O I：

10.1155/2014/387309

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by spectral data and elemental analyses. The synthesized compounds showed low enzyme inhibitory activity. However, they displayed good antimicrobial activity profile. Antibacterial activity of compounds 4a, 4e, and4p (MIC= 25 mu g/mL) was equal to that of chloramphenicol against Klebsiella pneumoniae (ATCC 700603) and Escherichia coli (ATCC 35218). Most of the compounds exhibited notable antifungal activity against Candida albicans (ATCC 10231), Candida glabrata (ATCC 90030), Candida krusei (ATCC 6258), and Candida parapsilosis (ATCC 7330). Moreover, compound 4a, which carries piperidin-1-yl substituent and dimethylthiocarbamoyl side chain as variable group, showed twofold better anticandidal effect against all Candida species than reference drug ketoconazole.

引用

页数：9

共 34 条

[1] Plants traditionally used in age related brain disorders -: A survey of ethnobotanical literature [J].