Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients

被引:35
作者
Mathur, Kushagra [1 ]
Agrawal, Rajat Kumar [1 ]
Nagpure, Shailesh [1 ]
Deshpande, Deepali [2 ]
机构
[1] Jawaharlal Nehru Med Coll, Dept Pharmacol, Sawangi 442001, Maharashtra, India
[2] Jawaharlal Nehru Med Coll, Cent Res Lab, Sawangi, Maharashtra, India
关键词
Artificial sweeteners; diabetes mellitus; glucose metabolism; HOMA-IR; insulin resistance; CONSUMPTION; GLUCOSE; RISK;
D O I
10.4103/jfmpc.jfmpc_329_19
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Introduction: Incidence of diabetes mellitus has increased over the past few years, mainly due to our eating habits and physical inactivity. This also includes the use of artificial sweetening agents which have broadly replaced other forms of sugars and have shown a paradoxical, negative effect on blood glucose. Ingestion of these artificial sweeteners (AS) results in the release of insulin from pancreas which is mistaken for glucose (due to their sweet taste). This increases the levels of insulin in blood eventually leading to decreased receptor activity due to insulin resistance. Methodology: It is a crosssectional study that was conducted on patients diagnosed with type-2 diabetes mellitus of a tertiary care hospital in Central India. All the diabetics that presented in the OPD were divided into 2 groups based on whether they use AS (group A) or not (group B). Insulin resistance was calculated for each group using HOMA-IR and graphs were plotted. Results: The HOMAIR values for Group A and B ranged from 0.9-24.33 and 0.12-10.83 with mean values 7.39 and 2.6, respectively, showing that the ones who used AS had a higher insulin resistance. The study also showed that the duration of use of artificial sweeteners had a direct impact on insulin resistance.
引用
收藏
页码:69 / 71
页数:3
相关论文
共 11 条
[1]  
Barnett A.H., 2012, TYPE 2 DIABETES, P162
[2]   Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men [J].
de Koning, Lawrence ;
Malik, Vasanti S. ;
Rimm, Eric B. ;
Willett, Walter C. ;
Hu, Frank B. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2011, 93 (06) :1321-1327
[3]   Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies [J].
Greenwood, D. C. ;
Threapleton, D. E. ;
Evans, C. E. L. ;
Cleghorn, C. L. ;
Nykjaer, C. ;
Woodhead, C. ;
Burley, V. J. .
BRITISH JOURNAL OF NUTRITION, 2014, 112 (05) :725-734
[4]   Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes [J].
Lofvenborg, Josefin E. ;
Andersson, Tomas ;
Carlsson, Per-Ola ;
Dorkhan, Mozhgan ;
Groop, Leif ;
Martinell, Mats ;
Tuomi, Tiinamaija ;
Wolk, Alicja ;
Carlsson, Sofia .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2016, 175 (06) :605-614
[5]   HOMEOSTASIS MODEL ASSESSMENT - INSULIN RESISTANCE AND BETA-CELL FUNCTION FROM FASTING PLASMA-GLUCOSE AND INSULIN CONCENTRATIONS IN MAN [J].
MATTHEWS, DR ;
HOSKER, JP ;
RUDENSKI, AS ;
NAYLOR, BA ;
TREACHER, DF ;
TURNER, RC .
DIABETOLOGIA, 1985, 28 (07) :412-419
[6]  
Mehnert H, 1979, ERGOB C SUG SUBST GE, P262
[7]   Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load [J].
Pepino, M. Yanina ;
Tiemann, Courtney D. ;
Patterson, Bruce W. ;
Wice, Burton M. ;
Klein, Samuel .
DIABETES CARE, 2013, 36 (09) :2530-2535
[8]   Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial [J].
Romo-Romo, Alonso ;
Aguilar-Salinas, Carlos A. ;
Brito-Cordova, Griselda X. ;
Gomez-Diaz, Rita A. ;
Almeda-Valdes, Paloma .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2018, 108 (03) :485-491
[9]   Natural and Artificial Sweeteners and High Fat Diet Modify Differential Taste Receptors, Insulin, and TLR4-Mediated Inflammatory Pathways in Adipose Tissues of Rats [J].
Sanchez-Tapia, Monica ;
Martinez-Medina, Jonathan ;
Tovar, Armando R. ;
Torres, Nimbe .
NUTRIENTS, 2019, 11 (04)
[10]   Low-calorie sweetener consumption is increasing in the United States [J].
Sylvetsky, Allison C. ;
Welsh, Jean A. ;
Brown, Rebecca J. ;
Vos, Miriam B. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (03) :640-646