Twelve-Week Jogging Training Increases Pre-Heparin Serum Lipoprotein Lipase Concentrations in Overweight/Obese Middle-Aged Men

Aim: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men. Methods: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL. Results: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean +/- SEM: 37.6 +/- 4.7 vs. 51.0 +/- 6.6 ng/mL, respectively, p = 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks. Conclusions: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men.