Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children

被引：34

作者：

Amre, D. K. ^{[1
,2
]}

Mack, D. R. ^{[3
]}

Morgan, K. ^{[4
,5
]}

Israel, D. ^{[6
]}

Deslandres, C. ^{[1
,2
]}

Seidman, E. G. ^{[5
,7
]}

Lambrette, P. ^{[8
]}

Costea, I. ^{[1
,9
]}

Krupoves, A. ^{[1
,9
]}

Fegury, H. ^{[1
]}

Dong, J. ^{[1
]}

Grimard, G. ^{[1
,9
]}

Levy, E. ^{[1
,10
]}

机构：

[1] Ste Justine Hosp, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Dept Pediat, Montreal, PQ H3C 3J7, Canada

[3] Childrens Hosp Eastern Ontario, Div Gastroenterol Hepatol & Nutr, Ottawa, ON K1H 8L1, Canada

[4] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[5] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ, Canada

[6] British Columbia Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, Vancouver, BC, Canada

[7] McGill Univ, Fac Med, Div Gastroenterol, Montreal, PQ, Canada

[8] Univ Montreal, Dept Prevent & Social Med, Montreal, PQ, Canada

[9] Univ Montreal, Dept Pediat, Div Orthoped, Montreal, PQ H3C 3J7, Canada

[10] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2010年 / 31卷 / 11期

基金：

加拿大健康研究院;

关键词：

INFLAMMATORY-BOWEL-DISEASE; GENE-WIDE; VARIANTS; EPIDEMIOLOGY; 21Q22; 20Q13;

D O I：

10.1111/j.1365-2036.2010.04294.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

P>Background Recent genome-wide association studies based on adult and paediatric populations have implicated > 30 genes/loci as susceptibility loci for Crohn's disease (CD). Aims To investigate whether reported genes/loci were also associated with CD in Canadian children. Design and Methods A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children < 18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. Results A total of 406 cases and 415 controls were studied. The mean (+/- s.d.) age of the cases was 12.3 (+/- 3.2) years. Most cases were male (56.6%), had ileo-colonic disease (L3 +/- L4, 52.0%) and inflammatory behaviour (B1 +/- p, 86.9%) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. Conclusion The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.

引用

页码：1186 / 1191

页数：6

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