Nematicidal amide alkaloids from the seeds of Clausena lansium

被引：25

作者：

Fan, Yu-Jiao ^{[2
]}

Chen, Hui-Qin ^{[1
]}

Mei, Wen-Li ^{[1
]}

Kong, Fan-Dong ^{[1
]}

Li, Fei-Xiang ^{[1
]}

Chen, Peng-Wei ^{[1
]}

Cai, Cai-Hong ^{[1
]}

Huang, Mian-Jia ^{[2
]}

Dai, Hao-Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China

[2] Hainan Univ, Coll Hort & Landscape Architecture, Haikou 570228, Hainan, Peoples R China

来源：

FITOTERAPIA | 2018年 / 128卷

关键词：

Clausena lansium; Seeds; Amide alkaloids; Nematicidal activity; CARBAZOLE ALKALOIDS; LOUR; SKEELS; CONSTITUENTS; COUMARINS; LEAVES; PEELS;

D O I：

10.1016/j.fitote.2018.04.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC50 value of 0.12 mM, while compounds 3 and 5 presented moderate nematicidal activity with IC50 values of 2.75 and 3.93 mM, respectively (abamectin as the positive control with IC50 value of 1.05 mM).

引用

页码：20 / 25

页数：6

共 50 条

[21] Phytochemical Study of Stem and Leaf of Clausena lansium
Peng, Wenwen
Fu, Xiaoxiang
Li, Yuyan
Xiong, Zhonghua
Shi, Xugen
Zhang, Fang
Huo, Guanghua
Li, Baotong
MOLECULES, 2019, 24 (17):
[22] Antifungal active ingredient from the twigs and leaves of Clausena lansium Lour. Skeels (Rutaceae)
Fu, Xiaoxiang
Xiao, Suling
Cao, Duantao
Yuan, Minxuan
Xiang, Miaolian
Zhou, Qinghong
Huang, Yingjin
Wei, Hongyi
Peng, Wenwen
FRONTIERS IN CHEMISTRY, 2022, 10
[23] Comprehensive Review of Phytochemical Profiles and Health-Promoting Effects of Different Portions of Wampee (Clausena lansium)
Huang, Xin
Wang, Minghe
Zhong, Saiyi
Xu, Baojun
ACS OMEGA, 2023, 8 (30): : 26699 - 26714
[24] Taxonomic significance and antitumor activity of alkaloids from Clausena lansium Lour. Skeels (Rutaceae)
Peng, Wen-Wen
Fu, Xiao-Xiang
Xiong, Zhong-Hua
Wu, Hong-Liang
Chang, Jing-Wen
Huo, Guang-Hua
Li, Bao-Tong
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2020, 90
[25] Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
Jiang, Hai Yan
Wang, Cheng Fang
Fan, Li
Yang, Kai
Feng, Jiang Bin
Geng, Zhu Feng
Xu, Jing
Deng, Zhi Wei
Du, Shu Shan
Yin, Hai Bo
MOLECULES, 2013, 18 (09) : 10768 - 10775
[26] Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
Shen, De-Yang
Kuo, Ping-Chung
Huang, Shiow-Chyn
Hwang, Tsong-Long
Chan, Yu-Yi
Shieh, Po-Chuen
Nguyen Thi Ngan
Tran Dinh Thang
Wu, Tian-Shung
JOURNAL OF NATURAL MEDICINES, 2017, 71 (01) : 96 - 104
[27] γ- and (δ-Lactams from the Leaves of Clausena lansium
Shen, De-Yang
Thi Ngan Nguyen
Wu, Shwu-Jen
Shiao, Young-Ji
Hung, Hsin-Yi
Kuo, Ping-Chung
Kuo, Daih-Huang
Tran Dinh Thang
Wu, Tian-Shung
JOURNAL OF NATURAL PRODUCTS, 2015, 78 (11): : 2521 - 2530
[28] The Clausena lansium (Wampee) genome reveal new insights into the carbazole alkaloids biosynthesis pathway
Fan, Yannan
Sahu, Sunil Kumar
Yang, Ting
Mu, Weixue
Wei, Jinpu
Cheng, Le
Yang, Jinlong
Liu, Jie
Zhao, Yuxian
Lisby, Michael
Liu, Huan
GENOMICS, 2021, 113 (05) : 3696 - 3704
[29] A New Furan-Coumarin from Clausena lansium
Peng, Wenwen
Zheng, Lixia
Huo, Guanghua
CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (03) : 440 - 442
[30] Two new cytotoxic constituents from the Clausena lansium (Lour.) Skeels
Jiang, Hai-Yan
Zhang, Wen-Juan
You, Chun-Xue
Yang, Kai
Fan, Li
Feng, Jiang-Bin
Chen, Jing
Yang, Ying-Jie
Wang, Cheng-Fang
Deng, Zhi-Wei
Yin, Hai-Bo
Du, Shu-Shan
PHYTOCHEMISTRY LETTERS, 2014, 9 : 92 - 95

← 1 2 3 4 5 →