Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor

被引：2

作者：

Higuchi, Masa-aki ^{[1
,2
]}

Roemmich, Ryan T. ^{[3
,4
]}

Martinez-Ramirez, Daniel ^{[1
,2
]}

Roper, Jaimie A. ^{[5
]}

Zukowski, Lisa A. ^{[6
]}

Foote, Kelly D. ^{[7
]}

Okun, Michael S. ^{[1
,2
,7
,8
,9
]}

Hass, Chris J. ^{[2
,10
]}

机构：

[1] Univ Florida, Dept Neurol, Fixel Inst Neurol Dis, Program Movement Disorders & Neurorestorat, Gainesville, FL USA

[2] Univ Florida, Program Movement Disorders & Neurorestorat, Gainesville, FL 32611 USA

[3] Kennedy Krieger Inst, Ctr Movement Studies, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA

[5] Auburn Univ, Sch Kinesiol, Auburn, AL 36849 USA

[6] High Point Univ, Congdon Sch Hlth Sci, Dept Phys Therapy, High Point, NC USA

[7] Univ Florida, Dept Neurosurg, Gainesville, FL USA

[8] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA

[9] Univ Florida, Dept Hist, Gainesville, FL USA

[10] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

来源：

TREMOR AND OTHER HYPERKINETIC MOVEMENTS | 2019年 / 9卷

基金：

美国国家卫生研究院;

关键词：

Essential tremor; gait; deep brain stimulation; Thalamus; Ataxia; PURKINJE-CELL LOSS; BALANCE CONFIDENCE; IMPAIRMENTS; DISORDER; ATAXIA;

D O I：

10.7916/tohm.v0.684

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established. Methods: We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus. Results: Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement. Discussion: These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.

引用

页码：1 / 6

页数：6

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