Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells

被引：28

作者：

Thapa, Punam ^{[1
]}

Lee, Yoo Jin ^{[2
]}

Tiep Tien Nguyen ^{[1
]}

Piao, Donglan ^{[2
]}

Lee, Hwaryeong ^{[2
]}

Han, Sujin ^{[2
]}

Lee, Yeon Jin ^{[2
]}

Han, Ah-Reum ^{[3
]}

Choi, Hyukjae ^{[1
]}

Jeong, Jee-Heon ^{[1
]}

Nam, Joo-Won ^{[1
]}

Seo, Eun Kyoung ^{[2
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea

[2] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea

[3] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup Si 56212, Jeollabuk Do, South Korea

来源：

MOLECULES | 2021年 / 26卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Alpinia oxyphylla; eudesmane sesquiterpene; eremophilane sesquiterpene; adipose-derived mesenchymal stem cell; antioxidant; oxidative stress;

D O I：

10.3390/molecules26061762

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alpinia oxyphylla Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7 alpha-hydroperoxy eudesma-3,11-diene-2-one (1) and 7 beta-hydroperoxy eudesma-3,11-diene-2-one (2), and a new eremophilane sesquiterpene, 3 alpha-hydroxynootkatone (3), were isolated from the MeOH extract of dried fruits of A. oxyphylla along with eleven known sesquiterpenes (4-14). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data. Compounds (1-3, 5-14) were evaluated for their protective effects against tert-butyl hydroperoxide (tBHP)-induced oxidative stress in adipose-derived mesenchymal stem cells (ADMSCs). As a result, treatment with isolated compounds, especially compounds 11 and 12, effectively reverted the damage of tBHP on ADMSCs in a dose-dependent manner. In particular, 11 and 12 at 50 mu M improved the viability of tBHP-toxified ADMSCs by 1.69 +/- 0.05-fold and 1.61 +/- 0.03-fold, respectively.

引用

页数：10

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