Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats

被引：43
作者：
Ho, YJ
Chang, YC
Liu, TM
Tai, MY
Wong, CS
Tsai, YF
机构：
[1] Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10018, Taiwan
[2] Tri Serv Gen Hosp, Dept Anesthesiol, Taipei, Taiwan
[3] Natl Def Med Ctr, Taipei, Taiwan
来源：
NEUROSCIENCE LETTERS | 2000年 / 287卷 / 02期
关键词：
glutamate; striatum; novelty stress; olfactory bulbectomy; microdialysis; hyperactivity;
D O I：
10.1016/S0304-3940(00)01152-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freely-moving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-field apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed significantly more locomotor activity (1210 +/- 270 cm) than sham-operated rats (420 +/- 70 cm), but only in the first 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163 +/- 21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These findings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：117 / 120
页数：4
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