Alpha-crystallin

被引：554

作者：

Horwitz, J ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2003年 / 76卷 / 02期

关键词：

alpha-crystallin; small heat-shock proteins; chaperones; aggregation; cataract;

D O I：

10.1016/S0014-4835(02)00278-6

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：145 / 153

页数：9

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