Clinicopathological characteristics of angiofibroma of soft tissue: report of three cases

Angiofibroma of soft tissue (AFST) is a recently-reported, rare, fibrovascular soft tissue neoplasm that commonly develops in the lower extremities of middle-aged women. Here, we report three cases located in the right temporal lobe of a woman, the left popliteal fossa of a female, and the right lower limb of a male patient, respectively, the former of which is first reported in the light of a literature review owing to its anatomical location. Histological and immunohistochemical features were consistent with the diagnosis of AFST. The two female patients have been individually followed up for 20 and 16 months after surgical resection without any local recurrences or any metastases. Meanwhile, we reviewed the clinicopathological characteristics of 81 AFST to further characterize this tumor. In addition, AFST is a benign tumor that should be considered in the differential diagnosis of a solitary fibrous tumor a low-grade fibromyxoid sarcoma, and low-grade myxofibrosarcoma, to avoid being misdiagnosed as malignant.