Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study

被引：6

作者：

Detering, Robin ^{[1
]}

Meyer, Vincent M. ^{[2
]}

Borstlap, Wernard A. A. ^{[1
]}

Beets-Tan, Regina G. H. ^{[3
]}

Marijnen, Corrie A. M. ^{[4
]}

Hompes, Roel ^{[1
]}

Tanis, Pieter J. ^{[1
]}

van Westreenen, Henderik L. ^{[2
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands

[2] Isala Hosp Zwolle, Dept Surg, Dr van Deenweg 1-11, NL-8025 AB Zwolle, Netherlands

[3] Antoni van Leeuwenhoek, Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands

[4] Antoni van Leeuwenhoek, Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2021年 / 124卷 / 03期

关键词：

chemoradiotherapy; disease-free survival; lymph nodes; rectal cancer; survival; PREOPERATIVE CHEMORADIOTHERAPY; NUMBER; TUMOR; IMPACT; CHEMORADIATION; YIELD; STAGE; RETRIEVAL; RADIATION; THERAPY;

D O I：

10.1002/jso.26522

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT). Methods: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I-III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Prognostic significance of LNC and LNR (cut-off values 0.15, 0.20, 0.30) was tested for different (sub)groups. Results: From 2095 registered patients, 458 were included, of which 240 patients with LNC < 12 and 218 patients with LNC >= 12. LNC was not significantly associated with DFS (p = 0.35) and OS (p = 0.59). In univariable analysis, LNR was significantly associated with DFS and OS in the whole cohort and LNC subgroups, but not in multivariable analysis. Conclusions: LNC was not associated with long-term oncological outcome in rectal cancer patients treated with CRT, nor was LNR when corrected for N-stage. However, LNR might be used to identify subgroups of node-positive patients with a favourable outcome.

引用

页码：367 / 377

页数：11

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