A two-step synthesis of cytostatically active benzo[c]phenanthridine derivatives

被引：56
|
作者：
Clement, B [1 ]
Weide, M [1 ]
Wolschendorf, U [1 ]
Kock, I [1 ]
机构：
[1] Univ Kiel, Inst Pharmazeut, Lehrstuhl Pharmazeut Chem, D-24118 Kiel, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 04期
关键词：
alkaloids; antitumor agents; benzophenanthridines; synthetic methods;
D O I：
10.1002/anie.200461969
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lots, fast: Benzo[c]phenanthridine derivatives are prepared efficiently by the reaction of aldehydes and 2-methylbenzonitrile in the presence of potassium tert-butanolate, followed by dehydration (see scheme). Some of these compounds demonstrate excellent cytostatic activity, and it is possible to introduce substituents directly into the basic molecular ring system.
引用
收藏
页码：635 / 638
页数：4
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