Transmembrane proteins of tight junctions

被引:123
作者
Balda, MS [1 ]
Matter, K [1 ]
机构
[1] Univ Geneva, Dept Biol Cellulaire, CH-1211 Geneva 4, Switzerland
关键词
tight junctions; zonula occludens; occludin; claudin; JAM;
D O I
10.1006/scdb.2000.0177
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tight junctions from a morphological and functional boundary between the apical and basolateral cell surface domains of epithelia and endothelia, and regulate selective diffusion along the paracellular space. Two types of four-span transmembrane proteins, occludin and claudins, as well as the single-span protein JAM are associated with tight junctions. The functional analysis of these proteins starts to reveal how they are involved in the functions of tight junctions, which of their domains are important for these functions, and how they: interact with each other to formulate junctional diffusion barriers.
引用
收藏
页码:281 / 289
页数:9
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