Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport

被引:23
作者
Scholz, Monika [1 ,2 ]
Burov, Stanislav [3 ]
Weirich, Kimberly L. [1 ,2 ]
Scholz, Bjoern J. [4 ,5 ,6 ]
Tabei, S. M. Ali [7 ]
Gardel, Margaret L. [1 ,2 ,6 ]
Dinner, Aaron R. [1 ,2 ,8 ]
机构
[1] Univ Chicago, James Franck Inst, 5640 S Ellis Ave, Chicago, IL 60637 USA
[2] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
[3] Bar Ilan Univ, Dept Phys, IL-5290002 Ramat Gan, Israel
[4] Univ Chicago, Enrico Fermi Inst, 5640 S Ellis Ave, Chicago, IL 60637 USA
[5] Univ Chicago, Kavli Inst Cosmol Phys, Chicago, IL 60637 USA
[6] Univ Chicago, Dept Phys, Chicago, IL 60637 USA
[7] Univ No Iowa, Dept Phys, Cedar Falls, IA 50614 USA
[8] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA
关键词
TUG-OF-WAR; BIDIRECTIONAL CARGO TRANSPORT; MOLECULAR MOTORS; ANOMALOUS DIFFUSION; DISORDERED-SYSTEMS; ACTIN NETWORKS; LIVING CELLS; SINGLE; KINESIN; DYNEIN;
D O I
10.1103/PhysRevX.6.011037
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function by controlling their cytoskeletal network structures locally.
引用
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页数:9
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