Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

被引：38

作者：

Ahlqvist, Grace P. ^{[1
]}

McGeough, Catherine P. ^{[1
]}

Senanayake, Chris ^{[2
]}

Armstrong, Joseph D. ^{[2
]}

Yadaw, Ajay ^{[2
]}

Roy, Sarabindu ^{[2
]}

Ahmad, Saeed ^{[3
]}

Snead, David R. ^{[3
]}

Jamison, Timothy F. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] TCG GreenChem Inc, Proc R&D Ctr Princeton South, Ewing, NJ 08628 USA

[3] Med All Inst, Richmond, VA 23298 USA

来源：

ACS OMEGA | 2021年 / 6卷 / 15期

基金：

美国国家科学基金会;

关键词：

LIPASE;

D O I：

10.1021/acsomega.1c00772

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed by transamination to yield the final drug product. Both steps have been successfully performed on a decagram scale: the first step at 200 g and the second step at 80 g. Overall, molnupiravir has been obtained in a 41% overall isolated yield compared to a maximum 17% isolated yield in the patented route. This route provides many advantages to the initial route described in the patent literature and would decrease the cost of this pharmaceutical should it prove safe and efficacious in ongoing clinical trials.

引用

收藏

页码：10396 / 10402

页数：7

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