Applications of serum albumins in delivery systems: Differences in interfacial behaviour and interacting abilities with polysaccharides

被引:54
作者
Aguilera-Garrido, Aixa [1 ]
del Castillo-Santaella, Teresa [1 ]
Yang, Yan [1 ]
Galisteo-Gonzalez, Francisco [1 ]
Jose Galvez-Ruiz, Maria [1 ,2 ]
Antonio Molina-Bolivar, Jose [2 ,3 ]
Antonio Holgado-Terriza, Juan [4 ]
Angel Cabrerizo-Vilchez, Miguel [1 ]
Maldonado-Valderrama, Julia [1 ,2 ]
机构
[1] Univ Granada, Dept Appl Phys, Ave Fuente Nueva S-N, Granada 18071, Spain
[2] Univ Granada, Excellence Res Unit Modeling Nat MNat, Avda Hosp S-N, Granada 18010, Spain
[3] Univ Malaga, Dept Appl Phys 2, Engn Sch, Malaga 29071, Spain
[4] Univ Granada, Dept Software Engn, C Periodista Daniel Saucedo Aranda S-N, Granada 18071, Spain
关键词
Albumin; Hyaluronic acid; Emulsion; Interfacial tension; Polysaccharide; zeta-Potential; Interaction; IN-WATER EMULSIONS; SUGAR-BEET PECTIN; QUARTZ-CRYSTAL MICROBALANCE; HYALURONIC-ACID; RHEOLOGICAL PROPERTIES; COMPETITIVE ADSORPTION; EMULSIFYING PROPERTIES; CONFORMATIONAL-CHANGES; BETA-LACTOGLOBULIN; GLOBULAR-PROTEINS;
D O I
10.1016/j.cis.2021.102365
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
One of the major applications of Serum Albumins is their use as delivery systems for lipophilic compounds in biomedicine. Their biomedical application is based on the similarity with Human Serum Albumin (HSA), as a fully biocompatible protein. In general, Bovine Serum Albumin (BSA) is treated as comparable to its human homologue and used as a model protein for fundamental studies since it is available in high amounts and well understood. This protein can act as a carrier for lipophilic compounds or as protective shell in an emulsion-based vehicle. Polysaccharides are generally included in these formulations in order to increase the stability and/or applicability of the carrier. In this review, the main biomedical applications of Albumins as drug delivery systems are first presented. Secondly, the differences between BSA and HSA are highlighted, exploring the similarities and differences between these proteins and their interaction with polysaccharides, both in solution and adsorbed at interfaces. Finally, the use of Albumins as emulsifiers for emulsion-based delivery systems, concretely as Liquid Lipid Nanocapsules (LLNs), is revised and discussed in terms of the differences encountered in the molecular structure and in the interfacial properties. The specific case of Hyaluronic Acid is considered as a promising additive with important applications in biomedicine. The literature works are thoroughly discussed highlighting similarities and differences between BSA and HSA and their interaction with polysaccharides encountered at different structural levels, hence providing routes to control the optimal design of delivery systems. (C) 2021 Published by Elsevier B.V.
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页数:16
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