Porphory-type Cu (Mo, Au) depositshave been discovered along the Gangdese magmatic arc in the southern Tibetan Plateau. Extensive field investigations and systematic studies of geochemistry, S-Pb isotopic tracing, together with Re-Os and 40Ar/39Ar isotopic dating indicate that the mineralisation of the cooper belt is genetically related to emplacement of late orogenic granitic porohyries during the post-collisional crustal relaxation period of the Late Himalayan epoch. These porphyries are petrochemically K-enriched and belong to chochonitic to high-K calc-alkaline series. They display enrichment of large ion lithophile elements (LILE) Rb, K, U, Th, Sr, Pb and depletion of high field strength elements (HFSE) Nb, Ta, Ti and the heavy rare earth elements (HREE) and Y without Eu anomolies. These characteristics demonstrate that subduction played a dominant role in their petrogenesis and residual gamet was left in the magma sources. Pb in the eastern segment of the copper belt to mantle Pb in the western segment. These constitute a mixing line of the Indian Oceanic MORB with Indian Oceanic sediments and suggest that the porphyry magmas were dominantly derived from partial melting ofsubducted oceanic crusts mixed with a minor quantity of sediments and mantle wedge components. The Gangdese porhyry copper polymetallic belt has alteration characteristics and zonation typical of porphyry-type copper deposits which include potassium a;teration (K-fieldspathisation and biotitisation), silicification, sericitisation, and propylitisation. Mineralisation mainly occurs in strongly altered granitic cataclasite at the exo-contact with veinlet-disseminated textures. The porphyries themselves are weakley mineralised with disseminated pyrite and chalcopyrite. The cooper deposits contain simple ore mineral associations consisting of chalcopyrite, pyrite, bornite, molybdite. During supergene oxidation, primary ores underwent secondary enrichment to form economic orebodies with Cu grade ranging from 1% to 5%. Ore sulphides of the cooper belt display S and Pb isotopic compositions identical to the ore-bearing porphyries. Their delta S-34 values vary between -3.8 parts per thousand and +2.4 parts per thousand and are typical of mantle sulphur. The Pb-206/Pb-204, Pb-207/Pb-204, and Pb-208/Pb-204 ratios vary in the ranges: 18.106 to 18.752, 15.501 to 15.638, and 37.394 to 39.058, respectively, and yielded radiogenetic lead-enriched signatures. Twelve molybdenite samples from the copper belt yielded isochron ages of 14.76 +/- 0.22 Ma and 13.99 +/- 0.16 Ma for the Nanmu and Chongjiang deposits and model ages of 13.5 to 13.6 Ma for the Lakang'e deposit. Meanwhile, 40Ar/39Ar isotopic dating of two biotite phenocrysts from the Chongjiang and Lakang'e deposits give plateau ages of 13.5 +/- 1.0 Ma and 13.42 +/- 0.10 Ma, respectively. During the geodynamic evolution of the Gangdese collision-orogenic belt, intrusion of the ore-bearing porphyries took place just before the rapid uplift and E-W extension of the southern Plateau. And the ore-forming process may have occurred simultaneously with the uplift and extension (14 +/- 0.1 Ma). (c) 2006 Elsevier B.V. All rights reserved.