Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis

被引：21
作者：
Vsiansky, Vit [1 ]
Gumulec, Jaromir [1 ,2 ]
Raudenska, Martina [2 ]
Masarik, Michal [1 ,2 ,3 ,4 ]
机构：
[1] Masaryk Univ, Fac Med, Dept Pathol Physiol, Kamenice 5, Brno 62500, Czech Republic
[2] Masaryk Univ, Fac Med, Dept Physiol, Kamenice 5, Brno 62500, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Katerinska 32, Prague 12108 2, Czech Republic
[4] Charles Univ Prague, BIOCEV, Katerinska 32, Prague 12108 2, Czech Republic
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词：
HEPATOCYTE GROWTH-FACTOR; GENE AMPLIFICATION; EXPRESSION; CARCINOMA; OVEREXPRESSION; METASTASIS; RESISTANCE; RECEPTOR; ACTIVATION; SURVIVAL;
D O I：
10.1038/s41598-018-28672-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
引用
收藏
页数：7
相关论文
共 32 条
  • [1] Aebersold DM, 2001, INT J CANCER, V96, P41, DOI 10.1002/1097-0215(20010220)96:1<41::AID-IJC5>3.0.CO
  • [2] 2-F
  • [3] [Anonymous], J CANC
  • [4] Combined CD44, c-MET, and EGFR expression in p16-positive and p16-negative head and neck squamous cell carcinomas
    Baschnagel, Andrew M.
    Tonlaar, Nathan
    Eskandari, Mohammad
    Kumar, Tripti
    Williams, Lindsay
    Hanna, Alaa
    Pruetz, Barbara L.
    Wilson, George D.
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2017, 46 (03) : 208 - 213
  • [5] Met, metastasis, motility and more
    Birchmeier, C
    Birchmeier, W
    Gherardi, E
    Vande Woude, GF
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (12) : 915 - 925
  • [6] Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model
    Brusevold, Ingvild J.
    Soland, Tine M.
    Khuu, Cuong
    Christoffersen, Thoralf
    Bryne, Magne
    [J]. EUROPEAN JOURNAL OF ORAL SCIENCES, 2010, 118 (04) : 342 - 349
  • [7] Prognostic value of cell motility activation factors in patients with tongue squamous cell carcinoma
    Endo, Kazuhira
    Shirai, Akiko
    Furukawa, Mitsuru
    Yoshizaki, Tomokazu
    [J]. HUMAN PATHOLOGY, 2006, 37 (08) : 1111 - 1116
  • [8] Biological predictors of radiosensitivity in head and neck squamous cell carcinoma
    Fiedler, Mathias
    Weber, Florian
    Hautmann, Matthias G.
    Haubner, Frank
    Reichert, Torsten E.
    Klingelhoeffer, Christoph
    Schreml, Stephan
    Meier, Johannes K.
    Hartmann, Arndt
    Ettl, Tobias
    [J]. CLINICAL ORAL INVESTIGATIONS, 2018, 22 (01) : 189 - 200
  • [9] Prognostic value of c-Met expression in oral squamous cell carcinoma
    Freudlsperger, Christian
    Alexander, Dorothea
    Reinert, Siegmar
    Hoffmann, Juergen
    [J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2010, 1 (01) : 69 - 72
  • [10] Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
    Grotegut, Stefan
    von Schweinitz, Dietrich
    Christofori, Gerhard
    Lehembre, Francois
    [J]. EMBO JOURNAL, 2006, 25 (15) : 3534 - 3545
1234