Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB)

被引：47

作者：

Adamowicz, Piotr ^{[1
]}

Zuba, Dariusz ^{[1
]}

Byrska, Bogumila ^{[1
]}

机构：

[1] Inst Forens Res, PL-31033 Krakow, Poland

来源：

FORENSIC SCIENCE INTERNATIONAL | 2014年 / 245卷

关键词：

3-MMC; 5-APB; Intoxication; Analysis; OF-THE-LITERATURE; MONOAMINE TRANSPORTERS; SYNTHETIC CATHINONES; MEPHEDRONE TOXICITY; CLINICAL TOXICOLOGY; RECREATIONAL DRUGS; BATH SALTS; DOPAMINE; AMPHETAMINE; RATS;

D O I：

10.1016/j.forsciint.2014.10.016

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The emergence of a large number of new psychoactive substances (NPSs) in recent years poses a serious problem to clinical and forensic toxicologists. Here we report a patient who administrated ca. 500 mg of 3-MMC (3-methyl-N-methylcathinone) and 400 mg of 5-APB (5-(2-aminopropyl)benzofuran) in combination with 80 g of ethyl alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. The patient did not recover and died around 4 h after the use of drugs. The cause of death was acute cardiovascular collapse that occurred following mixed intoxication with NPSs and alcohol. Toxicological analysis of post-mortem blood revealed 3-MMC and 5-APB in concentrations of 1.6 mu g/mL and 5.6 mu g/mL, respectively. Moreover, the serum alcohol concentration was 1.4 g/L in ante-mortem sample collected 1 h after admission to the hospital. This is the first report on blood concentration of 3-MMC and 5-APB in fatal intoxication. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：126 / 132

页数：7

共 33 条

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