Evidences of the radiofrequency exposure on the antioxidant status, potentially contributing to the inflammatory response and demyelination in rat brain

被引：1

作者：

Sharma, Anjali ^{[1
]}

Shrivastava, Sadhana ^{[2
]}

Singh, Asha ^{[2
]}

Gupte, Shamli S. ^{[2
]}

Rathour, Arti ^{[2
]}

Reshi, Mohd Salim ^{[3
]}

Shukla, Sangeeta ^{[2
]}

机构：

[1] Weill Cornell Med, Feil Family Brain & Mind Res Inst, Helen & Robert Appel Alzheimers Dis Res Inst, 413 E 69th St, New York, NY 10021 USA

[2] Jiwaji Univ, UNESCO Trace Element & Satellite Ctr, Sch Studies Zool, Gwalior 474011, Madhya Pradesh, India

[3] Baba Gulam Shah Univ, Sch Biosci & Biotechnol, Dept Zool, Toxicol & Pharmacol Lab, Rajouri 185234, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2022年 / 94卷

关键词：

Inflammation; Electromagnetic radiations; Myelination; Brain; Oxidative stress; ELECTROMAGNETIC-FIELD EXPOSURE; MOBILE PHONE RADIATION; OXIDATIVE STRESS; MULTIPLE-SCLEROSIS; CORPUS-CALLOSUM; GLUTATHIONE; CYTOKINES; NEURONS; DAMAGE; CELLS;

D O I：

10.1016/j.etap.2022.103903

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Present study exhibited the oxidative potential of microwave radiation (MWR) leading to the neurodegeneration in rats. Wistar rats were exposed at 2100 MHz frequency for 4 h/day, 5 days/week/3 months. Animals were exposed at an estimated specific absorption rate (0.453 W/kg) and power density (8.237 mu W/m(2)). After exposure irradiated group was compared with control group. Results indicated that microwave exposure significantly increased the levels of serological triglycerides and cholesterol. Oxidative stress is observed through alteration of glutathione homeostasis followed by activated inflammatory response further confirmed by pro and anti-inflammatory cytokines in the exposed group. Histopathological assessments and electron microscopic observation confirmed a significant change in the myelination pattern and cellular organelles in the brain of exposed animals. Taking everything into account it can be concluded that chronic exposure of 2100-MHz frequency caused oxidative stress, which leads to neural damage and demyelination and may affect neural communication.

引用

页数：14

共 71 条

[1]

Achudume AC., 2009, BIOL MED, V1, P33

[2] Role of lipids in brain injury and diseases [J].