Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature

被引：558

作者：

Viswanathan, S. ^{[1
]}

Shi, Y. ^{[2
,3
]}

Galipeau, J. ^{[4
]}

Krampera, M. ^{[5
]}

Leblanc, K. ^{[6
]}

Martin, I ^{[7
]}

Nolta, J. ^{[8
,9
]}

Phinney, D. G. ^{[10
]}

Sensebe, L. ^{[11
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Inst Biomat & Biomed Engn, Cell Therapy Program,Krembil Res Inst,Arthrit Pro, Toronto, ON, Canada

[2] Soochow Univ, Inst Translat Med, Affiliated Hosp 1, Suzhou, Peoples R China

[3] Chinese Acad Sci, Inst Hlth Sci, Shanghai, Peoples R China

[4] Univ Wisconsin, Dept Med, Carbone Canc Ctr, Madison, WI USA

[5] Univ Verona, Dept Med, Sect Hematol, Verona, Italy

[6] Karolinska Inst, Div Clin Immunol & Transfus Med, Stockholm, Sweden

[7] Univ Hosp Basel, Dept Biomed, Basel, Switzerland

[8] Univ Calif Davis, Dept Internal Med, Stem Cell Program, Sacramento, CA 95817 USA

[9] Univ Calif Davis, Inst Regenerat Cures, Sacramento, CA 95817 USA

[10] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL USA

[11] CNRS EFS UPS INSERM U1031, UMR5273, STROMALab, Jupiter, FL USA

来源：

CYTOTHERAPY | 2019年 / 21卷 / 10期

关键词：

differentiation; immunomodulation; mesenchymal stromal cells; nomenclature; paracrine secretion; self-renewal; stem cells; IN-VITRO; INTRAFEMORAL TRANSPLANTATION; BONE; MSC; EXPRESSION; DIFFERENTIATE; PROGENITORS; PERICYTES; CAPACITY; REVEALS;

D O I：

10.1016/j.jcyt.2019.08.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The International Society for Cell & Gene Therapy (ISCT (R)) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.

引用

页码：1019 / 1024

页数：6

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