NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline

被引：13
作者：
Delaby, Constance [1 ,2 ]
Julian, A. [3 ,4 ,5 ,6 ,7 ]
Page, G. [3 ,4 ]
Ragot, S. [7 ]
Lehmann, Sylvain [1 ]
Paccalin, M. [3 ,4 ,5 ,6 ,7 ]
机构：
[1] Univ Montpellier, CHU Montpellier, INSERM, Lab Biochim Proteom,INM,IRMB, Montpellier, France
[2] Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
[3] Univ Poitiers, EA3808 NEUVACOD Neurovasc Unit, Poitiers, France
[4] Univ Poitiers, Cognit Disorders, Poitiers, France
[5] Univ Poitiers Hosp, Memory Ctr Resources, Poitiers, France
[6] Univ Poitiers Hosp, Memory Ctr Res, Poitiers, France
[7] Univ Poitiers Hosp, Ctr Invest Clin CIC1402, INSERM, Poitiers, France
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
关键词：
NECROSIS-FACTOR DEATH; ALZHEIMERS-DISEASE; CHEMOKINE RECEPTORS; BETA GENERATION; INFLAMMATION; ALPHA; IMPAIRMENT; NEUROINFLAMMATION; ASTROCYTES; DIAGNOSIS;
D O I：
10.1038/s41598-021-89749-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1 beta, IL-6, TNF alpha, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.
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页数：7
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