Hantaviruses: Immunology, treatment, and prevention

被引：120
作者：
Maes, P
Clement, J
Gavrilovskaya, I
Van Ranst, M [1 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Lab Clin Virol, Louvain, Belgium
[2] SUNY Stony Brook, Dept Med, Stony Brook, NY USA
来源：
VIRAL IMMUNOLOGY | 2004年 / 17卷 / 04期
关键词：
D O I：
10.1089/vim.2004.17.481
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.
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页码：481 / 497
页数：17
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