Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age

被引：8

作者：

Devilli, Lara ^{[1
]}

Garonzi, Chiara ^{[1
]}

Balter, Rita ^{[1
]}

Bonetti, Elisa ^{[1
]}

Chinello, Matteo ^{[1
]}

Zaccaron, Ada ^{[1
]}

Vitale, Virginia ^{[1
]}

De Bortoli, Massimilano ^{[1
]}

Caddeo, Giulia ^{[1
]}

Baretta, Valentina ^{[1
]}

Tridello, Gloria ^{[1
]}

Cesaro, Simone ^{[1
]}

机构：

[1] Azienda Osped Univ Integrata, Dept Mother & Child, Pediat Hematol Oncol, Verona, Italy

来源：

HEMATOLOGY REPORTS | 2021年 / 13卷 / 01期

关键词：

acute lymphoblastic leukemia; pediatric leukemia; survival; AIEOP-BFM; CHILDREN; OSTEONECROSIS; ADOLESCENTS; FERTILITY;

D O I：

10.4081/hr.2021.8847

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Long-term survival for acute lymphoblastic leukemia (ALL) in children improved over the last three decades up to 80-90% of affected patients. Consequently, the quality of life of survivors has become increasingly important. This study analyses the clinical features and outcome of 119 children with ALL, focusing on the quality of long-term survival in a subset of 22 patients over 18 years of age. Among this group, the 10-year event-free survival and overall survival were 83.1% (C.I. 74.0-89.2) and 88.4% (C.I. 80.9-93.1), respectively. Treatment related long-term medical complications were reported only in 2 patients (9.1%). Secondary school was completed successfully in 20 of 22 patients (89.9%). The remaining 2 patients were still attending at the time of the analysis. In conclusion, current treatment for ALL is well tolerated and does not compromise significantly the quality of life of survivors.

引用

页码：17 / 20

页数：4

共 19 条

[1] Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia [J].

Byrne, J ;

Fears, TR ;

Mills, JL ;

Zeltzer, LK ;

Sklar, C ;

Nicholson, HS ;

Haupt, R ;

Reaman, GH ;

Meadows, AT ;

Robison, LL .

PEDIATRIC BLOOD & CANCER, 2004, 42 (07) :589-597

[2] Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia [J].

Conter, V. ;

Arico, M. ;

Basso, G. ;

Biondi, A. ;

Barisone, E. ;

Messina, C. ;

Parasole, R. ;

De Rossi, G. ;

Locatelli, F. ;

Pession, A. ;

Santoro, N. ;

Micalizzi, C. ;

Citterio, M. ;

Rizzari, C. ;

Silvestri, D. ;

Rondelli, R. ;

Lo Nigro, L. ;

Ziino, O. ;

Testi, A. M. ;

Masera, G. ;

Valsecchi, M. G. .

LEUKEMIA, 2010, 24 (02) :255-264

[3] Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study [J].

Conter, Valentino ;

Bartram, Claus R. ;

Valsecchi, Maria Grazia ;

Schrauder, Andre ;

Panzer-Gruemayer, Renate ;

Moericke, Anja ;

Arico, Maurizio ;

Zimmermann, Martin ;

Mann, Georg ;

De Rossi, Giulio ;

Stanulla, Martin ;

Locatelli, Franco ;

Basso, Giuseppe ;

Niggli, Felix ;

Barisone, Elena ;

Henze, Guenter ;

Ludwig, Wolf-Dieter ;

Haas, Oskar A. ;

Cazzaniga, Giovanni ;

Koehler, Rolf ;

Silvestri, Daniela ;

Bradtke, Jutta ;

Parasole, Rosanna ;

Beier, Rita ;

van Dongen, Jacques J. M. ;

Biondi, Andrea ;

Schrappe, Martin .

BLOOD, 2010, 115 (16) :3206-3214

[4] Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group [J].

Hunger, Stephen P. ;

Lu, Xiaomin ;

Devidas, Meenakshi ;

Camitta, Bruce M. ;

Gaynon, Paul S. ;

Winick, Naomi J. ;

Reaman, Gregory H. ;

Carroll, William L. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (14) :1663-1669

[5] Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia [J].

Jahnukainen, Kirsi ;

Heikkinen, Risto ;

Henriksson, Markus ;

Cooper, Trevor G. ;

Puukko-Viertomies, Leena-Riitta ;

Makitie, Outi .

FERTILITY AND STERILITY, 2011, 96 (04) :837-842

[6] Utility of Early Screening Magnetic Resonance Imaging for Extensive Hip Osteonecrosis in Pediatric Patients Treated With Glucocorticoids [J].

Kaste, Sue C. ;

Pei, Deqing ;

Cheng, Cheng ;

Neel, Michael D. ;

Bowman, W. Paul ;

Ribeiro, Raul C. ;

Metzger, Monika L. ;

Bhojwani, Deepa ;

Inaba, Hiroto ;

Campbell, Patrick ;

Rubnitz, Jeffrey E. ;

Jeha, Sima ;

Sandlund, John T. ;

Downing, James R. ;

Relling, Mary V. ;

Pui, Ching-Hon ;

Howard, Scott C. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (06) :610-U117

[7] Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia [J].

Kawedia, Jitesh D. ;

Kaste, Sue C. ;

Pei, Deqing ;

Panetta, John C. ;

Cai, Xiangjun ;

Cheng, Cheng ;

Neale, Geoffrey ;

Howard, Scott C. ;

Evans, William E. ;

Pui, Ching-Hon ;

Relling, Mary V. .

BLOOD, 2011, 117 (08) :2340-2347

[8] Late Effects of Therapy in Childhood Acute Lymphoblastic Leukemia Survivors [J].

Kizilocak, Hande ;

Okcu, Fatih .

TURKISH JOURNAL OF HEMATOLOGY, 2019, 36 (01) :1-11

[9] Osteonecrosis in children with acute lymphoblastic leukemia [J].

Kunstreich, Marina ;

Kummer, Sebastian ;

Laws, Hans-Juergen ;

Borkhardt, Arndt ;

Kuhlen, Michaela .

HAEMATOLOGICA, 2016, 101 (11) :1295-1305

[10] Long-term survival and quality of life in patients treated with a national ALL protocol 15-20 years earlier: IDM/HDM and late effects? [J].

Moe, PJ ;

Holen, A ;

Glomstein, A ;

Madsen, B ;

Hellebostad, M ;

Stokland, T ;

Wefring, KW ;

SteenJohnsen, J ;

Nielsen, B ;

Howlid, H ;

Borsting, S ;

Hapnes, C .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1997, 14 (06) :513-524

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