Synthesis of a coumarin-based europium complex for bioanalyte labeling

被引：32
作者：
Feau, Clementine
Klein, Emmanuel
Kerth, Paul
Lebeau, Luc
机构：
[1] Univ Strasbourg 1, CNRS, Inst Gilbert Laustriat, Fac Pharm, F-67401 Illkirch Graffenstaden, France
[2] Preventor uTBC GmbH, D-64319 Pfungstadt, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期
关键词：
coumarin; europium chelate; probe; homogeneous time-resolved fluorescence; light emitting diodes;
D O I：
10.1016/j.bmcl.2007.01.010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A coumarin-based curopium chelate ready-to-use for analyte labeling and homogeneous time-resolved fluorescence measurements has been designed. Compound 1 displays three functional elements: an azide reactive spacer arm, a coumarin sensitizer, and a seven-coordinate europium complex. That complex can be excited at 370 nm by inexpensive UV-LEDs as a light excitation source. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1499 / 1503
页数：5
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