Mental Retardation and Consanguinity in a Selected Region of the Israeli Arab Community

被引：6

作者：

Sharkia, Rajach ^{[1
,2
]}

Azem, Abdussalam ^{[3
]}

Kaiyal, Qassem ^{[4
]}

Zelnik, Nathanel ^{[4
]}

Mahajnah, Muhammad ^{[4
]}

机构：

[1] Triangle Reg Res & Dev Ctr, IL-30075 Kfar Qari, Israel

[2] Beit Berl Acad Coll, IL-44905 Beit Berl, Israel

[3] Tel Aviv Univ, Dept Biochem, Fac Life Sci, IL-69978 Tel Aviv, Israel

[4] Technion Israel Inst Technol, Rappaport Fac Med, Carmel Med Ctr, Child Neurol & Dev Ctr, IL-31096 Haifa, Israel

来源：

CENTRAL EUROPEAN JOURNAL OF MEDICINE | 2010年 / 5卷 / 01期

关键词：

Mental Retardation; Consanguinity; Hereditary diseases; PALESTINIAN ARABS; PREVALENCE; MALFORMATIONS; POPULATION; DISORDERS; MARRIAGES; DISEASES; CHILDREN;

D O I：

10.2478/s11536-009-0112-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of genetic diseases and congenital malformation in the Israeli Arab community is relatively high, but its distribution is not uniform. The aim of this study was to estimate the frequency of mental retardation disorders in children living in 5 Israeli Arab villages and determine its association with consanguinity. Mental retardation was found to affect 300 children in the screened population, yielding an overall prevalence of 14.5 per 1000. Most of those affected (68%) were the offspring of consanguineous marriages. One village with a high prevalence (4.3%) of neurological hereditary diseases was studied in detail. The prevalence of neurological hereditary diseases and mental retardation associated with consanguinity in these children highlights the need to implement appropriate preventive program.

引用

页码：91 / 96

页数：6

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