MDR1 polymorphism influences the outcome of multiple myeloma patients

被引：38

作者：

Buda, Gabriele ^{[1
]}

Maggini, Valentina

Galimberti, Sara

Martino, Alessandro

Giuliani, Nicola

Morabito, Fortunato

Genestreti, Giovenzio

Iacopino, Pasquale

Rizzoli, Vittorio

Barale, Roberto

Rossi, Anna M.

Petrini, Mario

机构：

[1] Univ Pisa, Sect Hematol, Dept Oncol Transplants & Adv Technol, Pisa, Italy

[2] Univ Pisa, Dept Biol, Pisa, Italy

[3] Univ Parma, Hematol & BMT Ctr, I-43100 Parma, Italy

[4] S Annunziata Hosp, Haematol Serv, Cosenza, Italy

[5] Osped Civile Infermi, Div Oncohematol, Rimini, Italy

[6] AO Reggio Calabria, Bone Marrow Transplant Unit, Calabria, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 137卷 / 05期

关键词：

multidrug resistance; multiple myeloma; chemotherapy;

D O I：

10.1111/j.1365-2141.2007.06605.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients. This study evaluated the prognostic role of MDR1 in the outcome of 115 multiple myeloma patients treated with DAV (dexamethasone, doxorubicin [adryamicin] and vincristine) regimen followed by autologous transplantation. In particular, when investigating the C3435T polymorphism, a prognostic value of MDR1 genotypes for overall survival (OS) was observed. Our data suggested a longer OS for patients with C/T and T/T genotypes (log-rank test, P = 0.02) compared with patients with C/C genotype.

引用

页码：454 / 456

页数：3

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