Local Thrombolysis for Acute Massive Pulmonary Embolism using a Pulse-Infusion-Thrombolysis Catheter

被引:0
作者
Ina, Yujiro [1 ,2 ]
Kondo, Katsuhiro [2 ]
Iwabuchi, Masashi [2 ]
Nobuyoshi, Masakiyo [2 ]
Kaminou, Toshio [1 ]
Ogawa, Toshihide [1 ]
机构
[1] Tottori Univ, Fac Med, Dept Pathophysiol Therapeut Sci, Div Radiol,Sch Med, Yonago, Tottori 6838504, Japan
[2] Kokura Mem Hosp, Clin Cardiol, Kitakyushu, Fukuoka 8028555, Japan
关键词
catheter; pulmonary embolism; thrombolysis; tissue plasminogen activator; PLASMINOGEN-ACTIVATOR; THERAPY; THROMBOEMBOLISM; FRAGMENTATION; EMBOLECTOMY; ASPIRATION; OUTCOMES;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Acute massive pulmonary embolism (PE) is a common life-threatening condition requiring emergent and suitable treatment. The aim of this study is to assess the efficacy and safety of local thrombolysis with a pulse-infusion-thrombolysis (PIT) catheter in the management of acute massive PE. Thirty-nine patients with PE were treated with catheter directed intervention (CDI). CDI involves suction embolectomy and local thrombolysis with a PIT catheter. Procedural success was achieved in all patients (100%). After the CDI, a significant increase of mean systemic blood pressure was observed (93.8 +/- 22.0 mmHg versus 100.8 +/- 22.9 mmHg, P = 0.02), and pulmonary perfusion on the basis of Miller score was improved (19.6 +/- 7.6 versus 16.3 +/- 7.1, P = 0.04). Clinical success was achieved in 36 of 39 patients (92.3%). Two patients died of PE after CDI despite a successful recanalization, and I patient died of disseminated intravascular coagulation after the CDI. No major complication occurred in the remaining 36 patients and minor complications developed in 3 patients (7.7%). Local thrombolysis using a PIT catheter for massive PE is safe and effective treatment with minimal complication.
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页码:17 / 24
页数:8
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