The human glucocorticoid receptor: Molecular basis of biologic function

被引：301

作者：

Nicolaides, Nicolas C. ^{[1
]}

Galata, Zoi ^{[1
]}

Kino, Tomoshige ^{[2
]}

Chrousos, George P. ^{[1
,2
,3
]}

Charmandari, Evangelia ^{[1
,2
,3
]}

机构：

[1] Acad Athens, Biomed Res Fdn, Clin Res Ctr, Div Endocrinol & Metab, Athens 11527, Greece

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Pediat Endocrinol, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA

[3] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Metab & Diabet,Dept Pediat 1, GR-11527 Athens, Greece

来源：

STEROIDS | 2010年 / 75卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Human glucocorticoid receptor (hGR); Generalized glucocorticoid resistance; Mutations in the hGR gene; Polymorphisms of the hGR gene; LIGAND-BINDING DOMAIN; UBIQUITIN-PROTEASOME PATHWAY; FRAGMENT-LENGTH-POLYMORPHISM; PRIMARY CORTISOL RESISTANCE; STEROID-HORMONE RECEPTORS; N-TERMINAL KINASE; BODY-MASS INDEX; FACTOR-KAPPA-B; NUCLEAR RECEPTOR; GENE-EXPRESSION;

D O I：

10.1016/j.steroids.2009.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The characterization of the subfamily of steroid hormone receptors has enhanced our understanding of how a set of hormonally derived lipophilic ligands controls cellular and molecular functions to influence development and help achieve homeostasis. The glucocorticoid receptor (GR), the first member of this subfamily, is a ubiquitously expressed intracellular protein, which functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes. The effector domains of the GR mediate transcriptional activation by recruiting coregulatory multi-subunit complexes that remodel chromatin, target initiation sites, and stabilize the RNA-polymerase II machinery for repeated rounds of transcription of target genes. This review summarizes the basic aspects of the structure and actions of the human (h) GR, and the molecular basis of its biologic functions. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1 / 12

页数：12

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