Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

被引：544
作者：
Liby, Karen T. [1 ]
Yore, Mark M. [1 ]
Sporn, Michael B. [1 ]
机构：
[1] Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03755 USA
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 05期
关键词：
D O I：
10.1038/nrc2129
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs. They are neither conventional cytotoxic agents, nor are they monofunctional drugs that uniquely target single steps in signal transduction pathways. Synthetic oleanane triterpenoids have profound effects on inflammation and the redox state of cells and tissues, as well as being potent anti- proliferative and pro- apoptotic agents. Rexinoids are ligands for the nuclear receptor transcription factors known as retinoid X receptors. Both classes of agents can prevent and treat cancer in experimental animals. These drugs have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti- cancer treatments.
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页码：357 / 369
页数：13
相关论文
共 170 条
[1]  
Agarwal VR, 2000, CANCER RES, V60, P6033
[2]   Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179 [J].
Ahmad, Rehan ;
Raina, Deepak ;
Meyer, Colin ;
Kharbanda, Surender ;
Kufe, Donald .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) :35764-35769
[3]   The tumour microenvironment as a target for chemoprevention [J].
Albini, Adriana ;
Sporn, Michael B. .
NATURE REVIEWS CANCER, 2007, 7 (02) :139-147
[4]   Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor [J].
Altucci, L ;
Rossin, A ;
Hirsch, O ;
Nebbioso, A ;
Vitoux, D ;
Wilhelm, E ;
Guidez, F ;
De Simone, M ;
Schiavone, EM ;
Grimwade, D ;
Zelent, A ;
de Thé, H ;
Gronemeyer, H .
CANCER RESEARCH, 2005, 65 (19) :8754-8765
[5]   Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid [J].
Balasubramanian, S ;
Chandraratna, RAS ;
Eckert, RL .
CARCINOGENESIS, 2004, 25 (08) :1377-1385
[6]   Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].
Balkwill, F ;
Charles, KA ;
Mantovani, A .
CANCER CELL, 2005, 7 (03) :211-217
[7]  
Barabasi A. L., 2000, LINKED EVERYTHING IS
[8]   High-throughput mapping of a dynamic signaling network in mammalian cells [J].
Barrios-Rodiles, M ;
Brown, KR ;
Ozdamar, B ;
Bose, R ;
Liu, Z ;
Donovan, RS ;
Shinjo, F ;
Liu, YM ;
Dembowy, J ;
Taylor, IW ;
Luga, V ;
Przulj, N ;
Robinson, M ;
Suzuki, H ;
Hayashizaki, Y ;
Jurisica, I ;
Wrana, JL .
SCIENCE, 2005, 307 (5715) :1621-1625
[9]   Mast cells in autoimmune disease [J].
Benoist, C ;
Mathis, D .
NATURE, 2002, 420 (6917) :875-878
[10]   TGFβ:: the molecular Jekyll and Hyde of cancer [J].
Bierie, Brian ;
Moses, Harold L. .
NATURE REVIEWS CANCER, 2006, 6 (07) :506-520
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