Ferromagnetic Gd5Si4 Nanoparticles as T2 Contrast Agents for Magnetic Resonance Imaging

被引：19
|
作者：
El-Gendy, Hmed A. [1 ,2 ,3 ]
Harstad, Shane M. [1 ]
Vijayaragavan, Vimalan [4 ]
Gupta, Shalabh [5 ]
Pecharsky, Vitalij K. [5 ,6 ]
Zweit, Jamal [4 ]
Hadimani, Ravi L. [1 ]
机构：
[1] Virginia Commonwealth Univ, Dept Mech & Nucl Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA
[2] Univ Texas El Paso, Dept Phys, El Paso, TX 79968 USA
[3] Natl Inst Stand, Nanotechnol & Nanometrol Lab, Giza 12211, Egypt
[4] Virginia Commonwealth Univ, Dept Radiol, Sch Med, Ctr Mol Imaging, Med Coll Virginia Campus, Richmond, VA 23284 USA
[5] USDA, Ames Lab, Div Mat Sci & Engn, Ames, IA 50011 USA
[6] Iowa State Univ, Dept Mat Sci & Engn, Ames, IA 5011 USA
来源：
IEEE MAGNETICS LETTERS | 2017年 / 8卷
关键词：
Biomagnetics; nanoparticles; magnetic resonance imaging; magnetic contrast agents; gadoliniumsilicide; SUPERPARAMAGNETIC IRON-OXIDE;
D O I：
10.1109/LMAG.2017.2728503
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Room temperature ferromagnetic Gd5Si4 nanoparticles were synthesized using arc-melting and high-energy ball milling. We demonstrate that these particles can be used as potential T2 contrast agents for magnetic resonance imaging (MRI). The ball-milled Gd5Si4 nanostructured material shows a ferromagnetic-to-paramagnetic transition at 320 K, revealing long-range magnetic order of the Gd5Si4 phase. Echo time was measured in a 7 T magnetic resonance imaging system and shows significant reduction compared to that reported for superparamagnetic iron oxide nanoparticles. These results show the potential of Gd5Si4 ferromagnetic nanoparticles as T2 contrast agents for MRI.
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页数：4
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