The association of gut microbiota characteristics in Malawian infants with growth and inflammation

被引：27

作者：

Kamng'ona, Arox W. ^{[1
]}

Young, Rebecca ^{[2
,3
]}

Arnold, Charles D. ^{[2
,3
]}

Kortekangas, Emma ^{[4
]}

Patson, Noel ^{[5
]}

Jorgensen, Josh M. ^{[2
,3
]}

Prado, Elizabeth L. ^{[2
,3
]}

Chaima, David ^{[5
]}

Malamba, Chikondi ^{[5
]}

Ashorn, Ulla ^{[4
]}

Fan, Yue-Mei ^{[4
]}

Cheung, Yin B. ^{[6
]}

Ashorn, Per ^{[4
,7
]}

Maleta, Kenneth ^{[5
]}

Dewey, Kathryn G. ^{[2
,3
]}

机构：

[1] Univ Malawi, Coll Med, Dept Biomed Sci, Blantyre, Malawi

[2] Univ Calif Davis, Program Int & Community Nutr, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[4] Univ Tampere, Fac Med & Hlth Technol, Ctr Child Hlth Res, Tampere, Finland

[5] Univ Malawi, Coll Med, Sch Publ Hlth & Family Med, Blantyre, Malawi

[6] Duke NUS Grad Med Sch, Ctr Quantitat Med, Singapore, Singapore

[7] Tampere Univ Hosp, Dept Paediat, Tampere, Finland

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

FECAL MICROBIOTA; BOWEL-DISEASE; RURAL MALAWI; CHILD GROWTH; SUPPLEMENTATION; DIVERSITY; PROFILES; OBESITY; IMPACT; DIET;

D O I：

10.1038/s41598-019-49274-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We tested the hypotheses that a more mature or diverse gut microbiota will be positively associated with infant growth and inversely associated with inflammation. We characterized gut microbiota from the stool samples of Malawian infants at 6 mo (n = 527), 12 mo (n = 632) and 18 mo (n = 629) of age. Microbiota diversity and maturity measurements were based on Shannon diversity index and microbiota for age Z-score (MAZ), respectively. Growth was calculated as change in Z-scores for weight-for-age (WAZ), length-for-age (LAZ) and head circumference-for-age (HCZ) from 6 to 12 mo and 12 to 18 mo. Biomarkers of inflammation (alpha-1-acid glycoprotein (AGP) and C-reactive protein (CRP)) were measured at 6 and 18 mo. Multivariable models were used to assess the association of each independent variable with each outcome. Microbiota diversity and maturity were related to growth in weight from 6 to 12 mo, but not to growth in length or head circumference or to growth from 12 to 18 mo. Microbiota diversity and maturity may also be linked to inflammation, but findings were inconsistent.

引用

页数：13

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