Blood-brain barrier peptide shuttles

被引：49

作者：

Sanchez-Navarro, Macarena ^{[1
]}

Giralt, Ernest ^{[1
,2
]}

Teixido, Meritxell ^{[1
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Res Biomed, Baldiri Reixac 10, Barcelona 08028, Spain

[2] Univ Barcelona, Dept Organ Chem, Barcelona, Spain

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2017年 / 38卷

关键词：

TARGETED DRUG-DELIVERY; CENTRAL-NERVOUS-SYSTEM; TRANSFERRIN RECEPTOR; GLIOMA THERAPY; GENE DELIVERY; BBB-SHUTTLES; MOUSE MODEL; TRANSPORT; NANOPARTICLES; ANGIOPEP-2;

D O I：

10.1016/j.cbpa.2017.04.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.

引用

页码：134 / 140

页数：7

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