The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

被引：5
|
作者：
Samara, Evangelia [1 ]
Stamatiou, Konstantinos [2 ]
Balanika, Marina [1 ]
Tzimas, Petros [3 ]
机构：
[1] Onassis Cardiac Surg Ctr, Dept Anaesthesiol, Athens, Greece
[2] Tzaneio Gen Hosp Piraeus, Dept Urol, Piraeus, Greece
[3] Univ Ioannina, Sch Hlth Sci, Dept Anesthesiol & Postoperat Intens Care, Ioannina, Greece
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 04期
关键词：
sugammadex; coagulation; bleeding; hemostasis; prothrombin time (pt); activated partial thromboplastin time (aptt); COAGULATION;
D O I：
10.7759/cureus.14521
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials' findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.
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页数：6
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