"Albumin Hitchhiking" with an Evans Blue Analog for Cancer Theranostics

被引：27
作者：
Ehlerding, Emily B. [1 ]
Lan, Xiaoli [2 ]
Cai, Weibo [1 ,3 ,4 ]
机构：
[1] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
[2] Huazhong Univ Sci & Technol, Union Hosp, Dept Nucl Med, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[3] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
[4] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53705 USA
来源：
THERANOSTICS | 2018年 / 8卷 / 03期
基金：
美国国家卫生研究院;
关键词：
somatostatin receptor 2 (SSTR2); peptide receptor radionuclide therapy (PRRT); octreotate (TATE); positron emission tomography (PET); theranostics; cancer; precision medicine; ANTIBODIES; THERAPY; BINDING; PET;
D O I：
10.7150/thno.24183
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although Lu-177-DOTA-TATE was recently approved in Europe for the treatment of certain neuroendocrine tumors, continued development and optimization has been ongoing to further improve the therapeutic efficacy of somatostatin receptor 2 targeted peptide receptor radionuclide therapy, as well as reducing the renal toxicity. In this work, the use of an Evans blue analog for "albumin hitchhiking" resulted in significant improvement in both the imaging performance and therapeutic efficacy of radiolabeled octreotate, as well as reducing the toxicity since much less radioactivity was used for therapy. Upon clinical translation, such "albumin hitchhiking" could make significant impact in the near future for cancer patient management.
引用
收藏
页码：812 / 814
页数：3
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